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4-hydroxy-2-quinolones. 202*. Synthesis, chemical and biological properties of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides |
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| Authors: | I V Ukrainets O V Bevz E V Mospanova L V Savchenkova S I Yankovich |
| Institution: | 1. National University of Pharmacy, 53 Pushkinska St., Kharkiv, 61002, Ukraine 2. Institute of Chemical Technology East Ukraine Volodymyr Dahl National University, 31 Lenin St., Rubezhnoe, 93003, Ukraine 3. Lugansk State Medicinal University, 1 50 year Lugansk Defense Quarter, Lugansk, 91045, Ukraine |
| Abstract: | In continuation of the search for potential analgesics amongst 4-hydroxyquinol-2-one derivatives we have proposed and carried out a preparative method of synthesis of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkylamides. It has been shown that bromination of 4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid allylamide using an equivalent of molecular bromine occurs with a conventional addition of the halogen to the allyl double bond and not with halocyclization. The results of the study of the analgesic properties of the compounds prepared are presented. |
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