System maps for retention of neutral organic compounds under isocratic conditions on a reversed-phase monolithic column |
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Authors: | Chu Yun Poole Colin F |
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Institution: | Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. |
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Abstract: | The solvation parameter model is used to create systems maps for the separation of neutral organic compounds on a Chromolith Performance RP-18e octadecylsiloxane-bonded silica-based monolithic column for water-acetonitrile and water-methanol mobile phase compositions from 10 to 70% (v/v) organic solvent. These results demonstrate that the retention properties of the monolithic column are similar to those of conventional octadecylsiloxane-bonded silica particle-packed columns. It is further shown that the selectivity for the monolithic column falls within the selectivity range for typical particle-packed columns at two mobile phase compositions for which a direct comparison is possible. |
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