Catalytic enantioselective alkene aminohalogenation/cyclization involving atom transfer |
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Authors: | Bovino Michael T Chemler Sherry R |
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Institution: | Department of Chemistry, The State University of New York at Buffalo, 14260, USA. |
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Abstract: | Problem solved: the title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines. Stereocenter formation is believed to occur by enantioselective cis?aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence. |
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Keywords: | aminohalogenation copper enantioselectivity homogeneous catalysis nitrogen heterocycles |
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