有机小分子催化的不对称Strecker反应研究进展

有机小分子催化的不对称合成反应是目前研究最为活跃的领域之一. 不对称Strecker反应是合成光学活性α-氨基酸衍生物的有效手段. 目前报道的催化不对称Strecker反应的有机催化剂主要有手性胍类、手性(硫)脲衍生物、氮-氧偶极化合物、手性Brønsted酸等, 取得了良好的催化活性和对映选择性. 对各类有机小分子催化剂在有机催化不对称Strecker反应中的应用研究进展, 以及催化剂结构与反应条件对催化活性和不对称诱导作用的影响进行了简要评述.

Developments in Organocatalytic Asymmetric Strecker Reactions

Organocatalytic asymmetric reaction is an increasingly active area in oraganic sythesis. Asymmetric Strecker reaction is a powerful tool for the synthesis of α-amino acids. The reported organocatalysts for asymmetric Strecker reaction include chiral guanidines, chiral (thio)urea derivatives, N-oxide compounds, chiral Brφnsted acids and so on, which can catalyze the asymmetric Strecker reaction with high catalytic activity and excellent enantioselectivity. The applications of various organocatalysts to asymmetric Strecker reactions are reviewed in this paper. The catalytic activity and the asymmetric induction influenced by the structure of organocatalysts and the reaction condition are also discussed.