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Determination of the enantiomeric composition of samples of cocaine by normal-phase high-performance liquid chromatography with UV detection |
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| Authors: | Robert R MacGregor Joanna S Fowler Alfred P Wolf |
| Institution: | Department of Chemistry, Brookhaven National Laboratory, Upton, NY 11973 USA |
| Abstract: | A high-performance liquid chromatographic method has been developed for the quantitation of the enantiomers of cocaine. Mixtures of the naturally occurring (−)-cocaine and synthetically produced (+)-cocaine were hydrolysed in water to (+) and (−)-benzoyl ecgonine. Esterification with an optically pure 2-octanol resulted in diastereoisomers that could be separated on bare silica gel using an acetonitrile-aqueous ammonium phosphate mobile phase. |
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