| 基于非生物折叠体的分子识别 |
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| 引用本文： | 李昌治,蒋锡夔,黎占亭,高翔,王全瑞.基于非生物折叠体的分子识别[J].有机化学,2007,26(2):188-196. |
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| 作者姓名： | 李昌治 蒋锡夔 黎占亭 高翔 王全瑞 |
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| 作者单位： | 1. 复旦大学化学系,上海,200433
2. 中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海,200032 |
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| 摘 要： | 利用分子自组装的方法控制大分子量的线性有机分子的构象是物理有机化学一个富于挑战性的研究课题. 近年来, 化学家已经成功利用不同的分子内非共价键作用力如氢键和疏溶剂作用等诱导线性分子的折叠乃至螺旋构象的产生. 综述了近年来这种新的非生物二级结构形式在分子识别研究中的应用.
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| 关 键 词： | 分子折叠体 分子识别 氢键 疏溶剂作用 二级结构 |
| 收稿时间： | 2005-9-14 |
| 修稿时间： | 2006-02-20 |
Foldamer-Based Molecular Recognition |
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| LI Chang-Zhi,JIANG Xi-Kui,LI Zhan-Ting,GAO Xiang,WANG Quan-Rui.Foldamer-Based Molecular Recognition[J].Chinese Journal of Organic Chemistry,2007,26(2):188-196. |
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| Authors: | LI Chang-Zhi JIANG Xi-Kui LI Zhan-Ting GAO Xiang WANG Quan-Rui |
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| Institution: | 1. Department of Chemistry, Fudan University, Shanghai 200433;2. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 |
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| Abstract: | One of the challenging fields in physical organic chemistry is the control of the conformation of large linear organic molecules. In recent years, different non-covalent forces, especially hydrogen bonding and hydrophobic interaction, have been successfully applied to induce the folded or helical conformations of linear organic molecules. This paper reviews the recent applications of this new class of non-biological sec- ondary structures in molecular recognition. |
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| Keywords: | foldamer molecular recognition hydrogen bonding hydrophobic interaction secondary struc- ture |
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