A practical approach to the synthesis of 2,4-disubstituted oxazoles from amino acids |
| |
| Authors: | Morwick Tina Hrapchak Matt DeTuri Molly Campbell Scot |
| |
| Institution: | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877-0368, USA. tmorwick@rdg.boehringer-ingleheim.com |
| |
| Abstract: | reaction: see text] A new sequence for the synthesis of various 2,4-disubstituted oxazoles from alpha-amino acids is reported. The method is shown to be general and incorporates the reagent combination, triphenylphosphine/hexachloroethane, for cyclodehydration of intermediate alpha-acylamino aldehydes. Implementation of this reagent system for the conversion of alpha-acylamino ketones to oxazoles is briefly investigated. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
