Oxidative cyclization of amino alcohols catalyzed by a CpIr complex. Synthesis of indoles, 1,2,3,4-tetrahydroquinolines,and 2,3,4,5-tetrahydro-1-benzazepine |
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Authors: | Fujita Ken-Ichi Yamamoto Kazunari Yamaguchi Ryohei |
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Affiliation: | Department of Natural Resources, Graduate School of Global Environmental Studies, Kyoto University, Japan. fujitak@kagaku.h.kyoto-u.ac.jp |
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Abstract: | [reaction: see text] A new iridium-catalyzed oxidative cyclization of amino alcohols has been revealed. Indole derivatives are synthesized in good to excellent yields from 2-aminophenethyl alcohols by means of a [CpIrCl(2)](2)/K(2)CO(3) catalytic system. The present catalytic system is also effective for syntheses of 1,2,3,4-tetrahydroquinolines from 3-(2-aminophenyl)propanols and 2,3,4,5-tetrahydro-1-benzazepine from 4-(2-aminophenyl)butanol. |
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