Asymmetric aldol reactions using chiral CF3-Oxazolidines (Fox) as chiral auxiliary |
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| Authors: | Arnaud Tessier Julien Pytkowicz Thierry Brigaud |
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| Affiliation: | Université de Cergy-Pontoise, UMR CNRS 8123, Laboratoire SOSCO, F-95000 Cergy-Pontoise, France |
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| Abstract: | The aldol reactions of amide enolates derived from a trifluoromethylated oxazolidine (Fox) chiral auxiliary occur in good yields with a moderate anti diastereoselectivity (Li and Na enolates) to a high syn diastereoselectivity (boron enolate). After removal, the Fox chiral auxiliary is very conveniently and efficiently recovered in basic conditions. |
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| Keywords: | Aldol reaction Oxazolidines Organofluorine chemistry Stereoselective synthesis |
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