| Cycloaddition of benzoheteroazepine II Reactions and conformations of cycloadducts on1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides |
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| 作者姓名： | 许家喜 吴海涛 金声 |
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| 作者单位： | College of Chemistry and Molecular Engineering，Peking University，Beijing 100871，China，College of Chemistry and Molecular Engineering，Peking University，Beijing 100871，China，College of Chemistry and Molecular Engineering，Peking University，Beijing 100871，China |
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| 基金项目： | Project (No. 29342036) supported by the Natural Science Foundation of China. |
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| 摘 要： | Benzodiazepine and benzothiazepine derivatives have been well known as therapeutically important compounds. Four new tricyclic heterocyclic compounds, 3a,4,5,11-tetrahydro-3H-1,2,4-triazolo4,3-d] 1, 5]benzothiazepines (3), 3a,4,5,11-tetrahydro-3H,6H-1,2,4-triazolo4,3-d]1,5]benzodiazepine (4), 3a, 4,5,11-tetrahydro-1,2,4-oxadiazolo4,5-d] 1,5]benzothiazepines (5, 6) and 3a,4,5,11-tetrahydro-6H-1, 2,4-oxadiazolo4, 5-d] 1, 5 ] benzodiazepines (7,8), have been synthesized by 1,3-dipolar cycloaddition reactions of 2, 3-dihydro-1, 5-benzothiazepines and 2, 3-dihydro-1H-1, 5-benzodiazepine with benzonitrile N-phenylimine and benzonitrile oxides, respectively. The conformations of some cycloadducts and cycloaddition mechanism are described.
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Cycloaddition of benzoheteroazepine II Reactions and conformations of cycloadducts on1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides |
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| XU,Jia-Xi WU,Hai-Tao JIN,ShengCollege of Chemistry and Molecular Engineering,Peking University,Beijing ,China.Cycloaddition of benzoheteroazepine II Reactions and conformations of cycloadducts on1,5-benzothiazepines and 1,5-benzodiazepines with nitrile imine and nitrile oxides[J].Chinese Journal of Chemistry,1999,17(1):84-91. |
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| Authors: | XU Jia-Xi WU Hai-Tao JIN ShengCollege of Chemistry and Molecular Engineering Peking University Beijing China |
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| Institution: | XU,Jia-Xi WU,Hai-Tao JIN,ShengCollege of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China |
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| Abstract: | Benzodiazepine and benzothiazepine derivatives have been well known as therapeutically important compounds. Four new tricyclic heterocyclic compounds, 3a,4,5,11-tetrahydro-3H-1,2,4-triazolo4,3-d] 1, 5]benzothiazepines (3), 3a,4,5,11-tetrahydro-3H,6H-1,2,4-triazolo4,3-d]1,5]benzodiazepine (4), 3a, 4,5,11-tetrahydro-1,2,4-oxadiazolo4,5-d] 1,5]benzothiazepines (5, 6) and 3a,4,5,11-tetrahydro-6H-1, 2,4-oxadiazolo4, 5-d] 1, 5 ] benzodiazepines (7,8), have been synthesized by 1,3-dipolar cycloaddition reactions of 2, 3-dihydro-1, 5-benzothiazepines and 2, 3-dihydro-1H-1, 5-benzodiazepine with benzonitrile N-phenylimine and benzonitrile oxides, respectively. The conformations of some cycloadducts and cycloaddition mechanism are described. |
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| Keywords: | Cycloaddition benzothiazepine triazole oxadiazole |
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