| 钌多吡啶配合物的合成及插入配体的位阻效应对键合DNA的影响 |
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| 引用本文： | 甄启雄,叶保辉,刘劲刚,计亮年,王雷. 钌多吡啶配合物的合成及插入配体的位阻效应对键合DNA的影响[J]. 高等学校化学学报, 1999, 20(11): 1661-1666 |
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| 作者姓名： | 甄启雄 叶保辉 刘劲刚 计亮年 王雷 |
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| 作者单位： | 1. 中山大学化学系, 广州 510275;2. 广州师范大学化学系, 广州 510400 |
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| 基金项目： | 国家自然科学基金，广东省自然科学基金，中国科学院上海有机化学研究所生命有机化学国家重点实验室资助 |
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| 摘 要： | 合成了2,3-二甲基-1,4,8,9-四氮三联苯(dmtatp)和2,3-二苯基-1,4,8,9-四氮三联苯(dptatp)两种新配体及它们与2,2′-联吡啶和钌(Ⅱ)的混配物[Ru(bpy)2dmtatp]2+(1)和[Ru(bpy)2dptatp]2+(2),用电子吸收光谱、稳态荧光、粘度测定和圆二色谱研究了配合物与小牛胸腺DNA的相互作用。结合我们以前对配合物[Ru(bpy)2tatp]2+(3)(tatp为1,4,8,9-四氮三联苯)与小牛胸腺DNA的作用研究,得出配合物与DNA的键合强度顺序为:[Ru(bpy)2tatp]2+>[Ru(bpy)2dptatp]2+>[Ru(bpy)2dmtatp]2+,这与插入配体的位阻效应的减少趋势相一致。同时,还测定了配合物与DNA的键合常数。
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| 关 键 词： | 多吡啶钌(Ⅱ) 小牛胸腺DNA 插入作用 位阻效应 |
| 收稿时间： | 1999-03-22 |
| 修稿时间： | 1999-03-22 |
Synthesis of Ruthenium Polypyridyl Complexes and the Steric Influence of the Intercalated Ligand on DNA-Binding |
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| ZHEN Qi-Xiong,YE Bao-Hui,LIU Jin-gang,JI Liang-Nian,WANG Lei. Synthesis of Ruthenium Polypyridyl Complexes and the Steric Influence of the Intercalated Ligand on DNA-Binding[J]. Chemical Research In Chinese Universities, 1999, 20(11): 1661-1666 |
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| Authors: | ZHEN Qi-Xiong YE Bao-Hui LIU Jin-gang JI Liang-Nian WANG Lei |
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| Affiliation: | 1. Department of Chemistry, Zhongshan University, Guangzhou 510275, China;2. Department of Chemistry, Normal University of Guangzhou, Guangzhou 510400, China |
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| Abstract: | Two structurally related ligands dmtatp(2,3-dimethyl-1,4,8,9-tetraazatriphenylene), dptatap(2,3-diphenyl-1,4,8,9-tetraazatriphenylene) and their ruthenium(Ⅱ) complexes [Ru(bpy)2dmtatp]2+(1) and [Ru(bpy)2dptatp]2+(2) were synthesized and characterized. Combined with the previous study data of [Ru(bpy)2tatp]2+(3, tatp=1,4,8,9-tetraazatriphenylene) the steric influence of the intercalated ligand of these complexes on DNA-binding were investigated by electronic absorption, steady state luminescence, CDspectra and viscosity measurement. All the data suggested that the complexes bind with DNA by intercalation and the order of binding affinities is 3>2>1, consistent with the reduced steric effect of the intercalated ligand. |
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| Keywords: | Ruthenium(Ⅱ) polypyridyl Calf thymus DNA Intercalation Steric effect |
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