反式二氯二氨合铂与核苷作用的13C核磁共振研究

本文用¹³C核磁共振法研究了反式二氯二氨合铂和胸苷、胞苷、鸟苷和5'-腺苷酸的作用,确定在中性介质中所生成配合物状态及其中铂与配体的健合形式,在此基础上讨论了顺、反式二氯二氨合铂具有不同抗癌行为的可能原因。

STUDY ON THE INTERACTION OF TRANS-[Pt(NH3)2Cl2] WITH NUCLEOSIDES BY 13C NMR

Interaction of trans-Pt(NH₃)₃Cl_{213C NMR. The formation of a series of complexes and the site of complexation of nucleosides (or nucleotide) to trans-Pt(NH3)2Cl2] in the reaction systems were ascertained. On the basis of the results obtained, a possible reasoning of different behaviours of cis-, trans-Pt(NH3)2 Cl2] in antitumour action was discussed.}