Palladium-catalyzed selective N-(hetero)arylation or N,N′-di(hetero)arylation of 1-aminoindoles |
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| Authors: | Samir Messaoudi |
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| Institution: | CNRS, BioCIS UMR 8076, Univ Paris-Sud, BioCIS UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, rue J.B. Clément, F-92296 Châtenay-Malabry, France |
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| Abstract: | The selective synthesis of N-(hetero)aryl-1-aminoindoles 3 from the corresponding N-aminoindoles and (hetero)aryl halides using a catalyst combination of Pd2(dba)3 associated to Josiphos is described. By switching to Xantphos as the ligand, the alternate catalytic system allows the coupling to proceed efficiently for the preparation of symmetrical and unsymmetrical N,N′-diaryl-1-aminoindole derivatives in good yields. |
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| Keywords: | Palladium Amination Cross-coupling N-Substituted 1-aminoindoles Homogeneous catalysis |
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