Synthesis of benzo[c]phenanthrene dihydrodiols |
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| Authors: | M. Croisy-Delcey Y. Ittah D.M. Jerina |
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| Affiliation: | Laboratory of Bioorganic Chemistry National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health Bethesda, Maryland 20205 U.S.A. |
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| Abstract: | Unlike most other alternant polycyclic aromatic hydrocarbons which are carcinogenic, benzo[c]phenanthrene has a “fjord region” instead of a “bay region”. For this reason, we have synthesized the three metabolically possible trans 1,2-, 3,4-, and 5,6-dihydrodiols to test them for carcinogenic activity. |
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