A total synthesis of (+)-brefeldin a |
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| Authors: | Takeshi Kitahara Kenji Mori Masanao Matsui |
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| Affiliation: | 1. The Institute of Physical and Chemical Research, 2-1 Hirosawa, Wako-shi, Saitama, 351, Japan;2. Department of Agricultural Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | A key intermediate, a substituted cyclopentanonitrile () with correct stereochemistry, was prepared from D-mannitol and converted to the Corey's intermediate () without a C15-epimer, which was finally transformed to (+)-brefeldin A. |
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