The thermolysin-catalyzed condensation reactions of n-substituted aspartic and glutamic acids with phenylalanine alkyl esters |
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| Authors: | Yoshikazu Isowa Muneki Ohmori Tetsuya Ichikawa Kaoru Mori Yuji Nonaka Kei-ichi Kihara Kiyotaka Oyama Heijiro Satoh Shigeaki Nishimura |
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| Affiliation: | Sagami Chemical Research Center, Nishi-Ohnuma, Sagamihara, Kanagawa 229, Japan;Research Laboratories, Toyo Soda Manufacturing Co. Ltd., Shin-Nanyo, Yamaguchi 746, Japan |
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| Abstract: | The title reactions occur with concurrent peptide synthesis and optical resolutions of racemic substrates. With this method, Z-L-Asp-L-Phe-OME, the precursor to the synthetic sweetner, could be obtained in high yield. |
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