2-Carbomethoxycyclopentenone as a synthon. synthesis of sarkomycin |
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| Authors: | John N Marx Gevork Minaskanian |
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| Institution: | Department of Chemistry, Texas Tech University, Lubbock, Texas 79409 U.S.A. |
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| Abstract: | The first regiospecific synthesis of sarkomycin (II), a compound active against ascites-type tumors, is reported. Treatment of 2-carbomythoxycyclopentenone (I) with Et2AlCN generated the carbon skeleton; aelective functional group manipulations then gave the keto lactone X and the protected hydroxy acid XI; and mild acid treatment of these led to sarkomycin. |
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