In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency |
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Authors: | Andersson C R Fryknäs M Rickardson L Larsson R Isaksson A Gustafsson M G |
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Affiliation: | The Linnaeus Center for Bioinformatics, Uppsala University, Uppsala, Sweden. |
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Abstract: | A major concern of chemogenomics is to associate drug activity with biological variables. Several reports have clustered cell line drug activity profiles as well as drug activity-gene expression correlation profiles and noted that the resulting groupings differ but still reflect mechanism of action. The present paper shows that these discrepancies can be viewed as a weighting of drug-drug distances, the weights depending on which cell lines the two drugs differ in. |
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