Structure of the products of oxidation of vindoline by the Sarett reagent

The oxidation of vindoline with the Sarett reagent has given five lactams the structures of which have been established on the basis of the results of instrumental methods of analysis (the x-ray structural method, and the PMR, mass, and IR spectroscopy). Two of the vindoline derivatives — 4-acetoxy-7,8-dihydroxy-16-methoxy-3-methoxycarbonyl-3,6-epoxy-7,8,9,19-tetradehydrovincaminoreine 7,9-betaine and 4-acetoxy-16-methoxy-3-methoxycarbonyl-1-methyl-7,8-dioxo-3,6-epoxyaspidospermidine — have been obtained for the first time and are new compounds.All-Union Scientific-Research Institute of Medicinal Plants, Moscow. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 551–556, July–August, 1988.