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Three-dimensional H spectroscopic imaging of cerebral metabolites in the rat using surface coils |
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| Authors: | E J Fernandez A A Maudsley T Higuchi and M W Weiner |
| Institution: | a Department of Radiology, University of California, San Francisco, USA b Department of Medicine, University of California, San Francisco, USA c Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA |
| Abstract: | Three dimensional metabolite maps of protonated metabolites were obtained using 1H magnetic resonance spectroscopic imaging at 7 T. Surface coils were used to increase sensitivity and spatial resolution significantly over a volume coil two-dimensional acquisition. Adiabatic pulses were employed to provide homogeneous B1 excitation and frequency selective refocusing over the volume of the rat brain. These techniques were employed to obtain three-dimensional spectroscopic imaging spectra from nominal voxel volumes of 9–30 μl from rat brain. The improved spatial resolution and sensitivity are also demonstrated with studies of focal ischemia in the rat. |
| Keywords: | Author Keywords: 1H spectroscopy Spectroscopic imaging Metabolite mapping Rat brain Surface coil |
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