| One-pot Sequential Reaction for the Synthesis of Polysubstituted 3-（3-Nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates |
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| 作者姓名： | Lili Zhang Jing Sun Chaoguo Yan |
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| 作者单位： | College of Chemistry ＆ Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China |
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| 摘 要： | The one-pot sequential reaction of arylamines, methyl propiolate and 2-aryl-3-nitrochromenes without any catalyst in refluxing ethanol afforded the polysubstituted 3-（3-nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates in good yields and with high diastereoselectivity. Reaction mechanism was believed involving the initial formation of β-enamino ester and sequential Michael addition.
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| 关 键 词： | 多取代 苯基 一锅反应 硝基 Michael加成 合成 非对映选择性 连续反应 |
One-pot Sequential Reaction for the Synthesis of Polysubstituted 3-（3-Nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates |
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| Lili Zhang,Jing Sun,Chaoguo Yan.One-pot Sequential Reaction for the Synthesis of Polysubstituted 3-（3-Nitro-2-phenylchroman-4-yl）-3-arylaminoacrylates[J].Chinese Journal of Chemistry,2013,31(12):1546-1550. |
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| Authors: | 《Chinese Journal of Chemistry》 |
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| Institution: | College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, China |
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| Abstract: | The one‐pot sequential reaction of arylamines, methyl propiolate and 2‐aryl‐3‐nitrochromenes without any catalyst in refluxing ethanol afforded the polysubstituted 3‐(3‐nitro‐2‐phenylchroman‐4‐yl)‐3‐arylaminoacrylates in good yields and with high diastereoselectivity. Reaction mechanism was believed involving the initial formation of β‐enamino ester and sequential Michael addition. |
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| Keywords: | chromene propiolate acrylate arylamine one-pot reaction diastereoselectivity |
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