Inhibitory effects of 1,3-selenazol-4-one derivatives on mushroom tyrosinase |
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Authors: | Koketsu Mamoru Choi Sang Yoon Ishihara Hideharu Lim Beong Ou Kim Hocheol Kim Sun Yeou |
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Institution: | Department of Chemistry, Faculty of Engineering, Gifu University, Seoul, Korea. |
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Abstract: | This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase were investigated. Compounds at a concentration of 500 microM exhibited 33.4-62.1% of inhibition on dopa oxidase activity of mushroom tyrosinase. Their inhibitory effects were higher than that of kojic acid (31.7%), a well known tyrosinase inhibitor. 2-(4-Methylphenyl)-1,3-selenazol-4-one (A) exhibited the strongest inhibitory effect among them dose-dependently and in competitive inhibition manner. |
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