Switch-peptides: controlling self-assembly of amyloid beta-derived peptides in vitro by consecutive triggering of acyl migrations |
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| Authors: | Dos Santos Sonia Chandravarkar Arunan Mandal Bhubaneswar Mimna Richard Murat Karine Saucède Lydiane Tella Patricia Tuchscherer Gabriele Mutter Manfred |
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| Affiliation: | Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Chemical Sciences and Engineering, CH-1015 Lausanne, Switzerland. |
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| Abstract: | The sequential triggering (Soff --> Son) of O, N-acyl migrations (AcM) by chemical and enzymatic methods (Ti) in peptides containing structure-disrupting switch-elements, S (switch-peptides), offers a novel tool for studying in statu nascendi the onset and inhibition of polypeptide folding and self-assembly as a key process in degenerative diseases. |
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