Antitumor activity of transition metal(II) complexes with all- trans retinoic acid |
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| Authors: | Liu Ying-mei Wang Liu-fang Wang Zhi-ping Zhang Zhi-hua Chen Yi-rong Xu Ji-wu |
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| Affiliation: | (1) National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P.R. China;(2) Lanzhou Medicine College, Lanzhou, 730000, P.R. China;(3) Analysis and Testing Centre of Gansu Province, Lanzhou, 730000, P.R. China |
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| Abstract: | Five complexes of transition metals with all-trans retinoic acid (HRA) have been prepared and characterized by elemental analysis, molar conductance, t.g.–d.t.a, i.r., and u.v.-vis. spectroscopy, and 1H-n.m.r. spectrometry. The general formula of these complexes is ML2 ·nH2O where L=RA, M=MnII, CoII, NiII, CuII, ZnII, and n=3 or 4. They have been studied for their antitumour activity against human bladder cancer line EJ (EJ cells) with respect to proliferation, induce differentiation, P21 and mutation P53 expressions in vitro. |
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