Synthesis of Imidazo[1′,5′:1,2]pyrido[3,4- b ]indole Derivatives |
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Authors: | Magdolna Solymár Márta Palkó Tamás Martinek Ferenc Fül?p |
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Abstract: | The reactions of 1,2,3,4-tetrahydro-β-carboline-1-carboxylic acid and its ethyl ester with alkyl and aryl isothiocyanates under mild conditions resulted in the corresponding thiohydantoin-fused tetrahydro-β-carbolines. Treatment of the ethyl ester with isocyanates furnished ethyl 2-alkyl- or arylcarbamoyl-1,2,3,4-tetrahydro-β-carboline-1-carboxylates which were transformed to hydantoin-fused tetrahydro-β-carbolines. The structures of the thiohydantoin compounds, involving two conformers and the presence of keto-enol tautomerism, were determined by NMR spectroscopy. |
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