Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway |
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| Authors: | Aida Maddahi Lars Edvinsson |
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| Institution: | (1) Division of Experimental Vascular Research, BMC A13, Lund University, 221 84 Lund, Sweden;(2) Department of Internal Medicine, Institute of Clinical Sciences, Lund University, Lund, Sweden |
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| Abstract: | Background MEK1/2 is a serine/threonine protein that phosphorylates extracellular signal-regulated kinase (ERK1/2). Cerebral ischemia
results in enhanced expression of cerebrovascular contractile receptors in the middle cerebral artery (MCA) leading to the
ischemic region. Here we explored the role of the MEK/ERK pathway in receptor expression following ischemic brain injury using
the specific MEK1 inhibitor U0126. |
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