4-Hydroxy-2-quinolones. 56. 4-(Adamant-1-yl)thiazolyl-2-amides of 1-R-4-Hydroxy-2-oxoquinoline-3-carboxylic Acids as Potential Antitubercular Agents |
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| Authors: | I V Ukrainets M Amer P A Bezuglyi O V Gorokhova L V Sidorenko A V Turov |
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| Institution: | (1) Ukrainian National Pharmaceutical Academy, Kharkov, 61002;(2) Taras Shevchenko National University, Kiev, 01030 |
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| Abstract: | The synthesis, antitubercular, anti-HIV, and antitumor activity of the 4-(adamant-1-yl)thiazolyl-2-amides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids have been studied. An efficient method for purifying the 4-hydroxy-2-oxoquinoline derivatives from their metal salts is proposed. |
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| Keywords: | adamantane 4-hydroxy-2-quinolone thiazole antitubercular activity |
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