(1) Department of Pharmacy, School of Pharmacy, Hebrew University, POB 12065, 91120 Jerusalem, Israel
Abstract:
A coacervation technique for microencapsulation using Eudragit Retard polymers poly(methyl methacrylates) substituted by
quaternary ammonium groups] as wall material is described, based upon phase separation using a cold chloroform-cyclohexane
mixture together with polyisobutylene as a stabilizer. The effect of various parameters on the nature and properties of the
microcapsules of potassium dichromate and paracetamol has been studied, in particular the alteration in wall content and structure
and release rate of contents. The microcapsules are discrete, their properties are reproducible, and various degrees of sustained
release are obtained.