| 2,4,6—三氧—1,3,5,2—三氮磷杂环己烷衍生物的合成及其抗肿瘤活性 |
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| 引用本文： | 卢水明 毛丽娟. 2,4,6—三氧—1,3,5,2—三氮磷杂环己烷衍生物的合成及其抗肿瘤活性[J]. 合成化学, 1998, 6(4): 335-338 |
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| 作者姓名： | 卢水明 毛丽娟 |
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| 作者单位： | 南开大学元素有机化学研究所 |
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| 摘 要： | 利用Ｎ，Ｎ－二（２－氯乙基）氨基磷酰二异氰酸酯和胺的加成反应，合成了２，４，６三氧－１，３，５，２三氮磷杂环己烷衍生物，它们的结构经＾１ＨＮＭＲ，ＩＲ和元素分析所证实。初步生物活性测试结果表明，部分化合物具有一定的抗肿瘤活性。
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| 关 键 词： | 三磷杂环己烷 相转移催化 合成 抗肿瘤活性 |
Synthesis of Novel Derivatives of 2,4,6 Trioxo 1,3,5,2 triazaphosphorine and Their Antitumor Activities |
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| Lu,Shui Ming Mao,Li Juan. Synthesis of Novel Derivatives of 2,4,6 Trioxo 1,3,5,2 triazaphosphorine and Their Antitumor Activities[J]. Chinese Journal of Synthetic Chemistry, 1998, 6(4): 335-338 |
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| Authors: | Lu Shui Ming Mao Li Juan |
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| Abstract: | Six new derivatives of 2,4,6 trioxo 1,3,5,2 triazaphosphorine have been synthesized by the reactions of N,N bis(2 chloroethyl)aminophosphoryldiisocyanate with amines. The structures of the products were confirmed by 1H NMR,IR and elemental analysis.The preliminary bioassay indicated that some of them had antitumor activities. |
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| Keywords: | Triazaphosphorine Phase transfer catalysis Synthesis Antitumor activities. |
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