Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures |
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| Authors: | Castonguay Annie Wilson Eleanor Al-Hajaj Noura Petitjean Laurène Paoletti Julie Maysinger Dusica Kakkar Ashok |
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| Institution: | Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec, H3A 2K6, Canada. |
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| Abstract: | A simple and versatile dendrimer based platform to deliver therapeutic agents at temperatures within the physiological range, is reported. Lipoic acid conjugated at the periphery of the thermosensitive dendrimer formulations undergoes slow and sustained release at 37-42 °C, and rescues the cells from oxidative stress and a pro-inflammatory endotoxic agent. |
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