Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells |
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| Authors: | Crossley Ellen L Issa Fatiah Scarf Alana M Kassiou Michael Rendina Louis M |
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| Institution: | School of Chemistry, The University of Sydney, Sydney NSW 2006, Australia. |
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| Abstract: | New 1,2-closo- and 7,8-nido-carboranylpyrazolopyrimidines bind to the translocator protein (TSPO) with high affinity, providing the first evidence of a unique two-site binding profile for the closo-carborane derivative. The boron-rich compounds can also deliver boron to human glioma cells far more effectively than clinical agents used in boron neutron capture therapy (BNCT). |
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