Development of the carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2-methoxybenzyl |
| |
Authors: | Muranaka Kazuhiro Ichikawa Satoshi Matsuda Akira |
| |
Institution: | Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. |
| |
Abstract: | The new carboxamide protecting group, 4-(tert-butyldimethylsiloxy)-2-methoxybenzyl (SiMB), has been developed. While this SiMB group can be removed using mild basic desilylation methods, it can also be deprotected under strongly acidic or oxidative conditions. An application of this group to simple carboxamide groups, as well as to more complex and acid-sensitive adenosine derivatives containing a cyclophane scaffold, was also demonstrated. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|