Crystal structure,thermal behavior,and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes |
| |
Authors: | Berta Holló Marko V Rodi? Ljiljana S Vojinovi?-Je?i? Vukosava ?ivkovi?-Radovanovi? Gordana Vu?kovi? Vukadin M Leovac Katalin Mészáros Szécsényi |
| |
Institution: | 1. Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovi?a 3, 21000, Novi Sad, Serbia 2. Faculty of Chemistry, University of Belgrade, P.O. Box 51, 11158, Belgrade, Serbia
|
| |
Abstract: | The synthesis of a potentially bioactive mixed-valence CoIII/CoII complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed CoIIIL2]CoIICl3 py]·Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It’s thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas CoL2]NO3·MeOH (1), CoL2]Br·MeOH (2), CoL2]HSO4·MeOH (3), CoL2]2CoII(NCS)4] (4), Co(HL)(L)]I2·2MeOH (5), and Co(HL)(L)]CoIICl4]·MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|