| 鲁米诺-过氧化氢化学发光体系测定利福平 |
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| 引用本文： | 陈文山,张迎雪.鲁米诺-过氧化氢化学发光体系测定利福平[J].化学研究,2004,15(1):37-39. |
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| 作者姓名： | 陈文山 张迎雪 |
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| 作者单位： | 琼州大学,环境科学研究所,海南,五指山,572200;琼州大学,环境科学研究所,海南,五指山,572200 |
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| 摘 要： | 基于鲁米诺在碱性条件下可以被H2O2氧化产生化学发光,利福平对此化学发光具有增敏作用这一现象,结合流动注射技术建立了一种直接测定利福平的流动注射化学发光新方法.该方法的线性范围在1.0×10-6～2.0×10-8g·mL-1,检出限为3.0×10-9g·mL-1,对5.0×10-7g·mL-1的利福平连续进行11次平行测定,其相对标准偏差为3.0%.该法已成功测定了利福平胶囊及眼药水中利福平的含量.
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| 关 键 词： | 化学发光 流动注射 利福平 鲁米诺-过氧化氢 |
| 文章编号： | 1008-1011(2004)01-0037-03 |
| 修稿时间： | 2003年6月13日 |
Determination of Rifampicin with Luminol-H2O2 Chemiluminescence System |
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| CHEN Wen-shan,ZHANG Ying-xue.Determination of Rifampicin with Luminol-H2O2 Chemiluminescence System[J].Chemical Research,2004,15(1):37-39. |
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| Authors: | CHEN Wen-shan ZHANG Ying-xue |
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| Abstract: | A method to determine rifampicin by flow injection coupled chemiluminescence reaction is developed, based on the chemiluminescence produced during the oxidation of luminol by H_2O_2 in alkaline solution. The chemiluminescence intensity is proportional to rifampicin concentration over the range 1.0×10~(-6)～2.0×10~(-8) g ·mL~(-1 )with a detection limit of 3.0× 10~(-9) g ·mL~(-1). 11 times of parallel determination of 5.0×10~(-7) g ·mL~(-1) rifampicin, show that the relative standard deviation(RSD) is 3.0 %. The method has been sucessfully applied to the determination of rifampicin in capsules and eye drops samples. The proposed method is simple,quick and sensitive. |
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| Keywords: | chemiluminescence flow injection analysis rifampicin luminol-H_2O_2 |
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