Total synthesis of microcarpalide |
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Authors: | Kumar Pradeep Naidu S Vasudeva |
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Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India. tripathi@dalton.ncl.res.in |
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Abstract: | [reaction: see text] An efficient, convergent approach for the total synthesis of microcarpalide (1) is described. The synthetic strategy features the Sharpless asymmetric dihydroxylation, regioselective epoxide opening with various nucleophiles such as a lithium acetylide and cuprates derived from the vinyl stannane and the vinyl iodide for the construction of a C7-C8 trans-double bond and Yamaguchi macrolactonization as the key steps. |
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