| An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes |
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| 引用本文： | Yu Li XIE Qin ZHU. An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes[J]. 中国化学快报, 2003, 14(1): 25-28 |
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| 作者姓名： | Yu Li XIE Qin ZHU |
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| 作者单位： | [1]StateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMateriaMedica,ShanghaiInstitutesforBiologicalSciences,Shanghai200031 [2]StateKeyLaboratoryofDrugResearch,ShanghaiInstituteofMate |
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| 摘 要： | A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphosphoates from aldchydes is described.This method was applied to the synthesis of novel catechol substituted bisphosphonates as the anti-osteoporosis agents.
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| 关 键 词： | BPs 1-羟基亚甲基-1 1-二磷酸 合成 HMBP 醛类化合物 骨质疏松症 抗骨质疏松制剂 |
An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes |
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| Yu Li XIE,Qin ZHU,Xing Rong QIN,Yu Yuan XIE. An Efficient Synthesis of Aromatic 1-Hydroxymethylene-1,1-bisphosphonates from Aldehydes[J]. Chinese Chemical Letters, 2003, 14(1): 25-28 |
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| Authors: | Yu Li XIE Qin ZHU Xing Rong QIN Yu Yuan XIE |
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| Abstract: | A simple and efficient procedure for synthesis of 1-hydroxymethylene-1,1-bisphos- phoates from aldehydes is described. This method was applied to the synthesis of novel catechol substituted bisphosphonates as the anti-osteoporosis agents. |
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| Keywords: | Bisphosphonate aldehydes catechol anti-osteoporosis. |
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