| 三异丙醇胺硼酸酯的合成与表征 |
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| 引用本文： | 王巍,修志明,王德利,徐天殊,郭佑铭,王丽萍.三异丙醇胺硼酸酯的合成与表征[J].吉林大学学报(理学版),2014,52(4):831-834. |
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| 作者姓名： | 王巍 修志明 王德利 徐天殊 郭佑铭 王丽萍 |
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| 作者单位： | 1. 长春工业大学人文信息学院 制药工程系, 长春 130122； 2. 吉林大学 生命科学学院, 长春 130012 |
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| 基金项目： | 吉林省自然科学基金(批准号:201015171);吉林省科技发展计划项目(批准号:201205017);吉林省医药产业发展专项基金(批准号:YYZX201150-2) |
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| 摘 要： | 以三异丙醇胺和硼酸为原料, 经酯化反应合成三异丙醇胺硼酸酯, 并用重结晶方法纯化, 制得高纯度的终产物, 产物结构通过质谱(MS)、 核磁共振氢谱(1H NMR)、 红外光谱(FTIR)等方法表征. 研究反应物物质的量比、 反应温度、 反应时间和共沸溶剂对合成反应的影响以及重结晶溶剂和溶剂比例对纯化效果的影响. 结果表明, 最优条件下合成的三异丙醇胺硼酸酯的质量分数为99.8%, 收率为87.1%.
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| 关 键 词： | 三异丙醇胺硼酸酯 合成 纯化 |
| 收稿时间： | 2013-12-06 |
Synthesis and Characterization of Triisopropanolamine Borate |
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| WANG Wei,XIU Zhiming,WANG Deli,XU Tianshu,GUO Youming,WANG Liping.Synthesis and Characterization of Triisopropanolamine Borate[J].Journal of Jilin University: Sci Ed,2014,52(4):831-834. |
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| Authors: | WANG Wei XIU Zhiming WANG Deli XU Tianshu GUO Youming WANG Liping |
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| Institution: | 1. Department of Pharmaceutical Engineering, College of Humanities & InformationChangchun University of Techonology, Changchun 130122, China;
2. College of Life Science, Jilin University, Changchun 130012, China |
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| Abstract: | Triisopropanolamine borate was synthesized through the esterification of triisopropanolamine and boric acid, and purified by recrystallization. The structure of triisopropanolamine borate was characterized by MS, 1H NMR and FTIR. Effects of raw material ratio, reaction temperature, reaction time, and reaction solvent on the synthesis, and those of recrystallization solvent and solvent ratio on the purification were investigated. The product was obtained with a purity of 99.8% and a yield of 87.1%, respectively. |
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| Keywords: | triisopropanolamine borate synthesis purification |
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