Functional β-Cyclodextrin Coating by Electrodeposition on Stainless Steel for Drug Loading and Release |
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| Authors: | CHEN Bin CHEN Jie YANG Liming ZHAO Guochen DING Guowei |
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| Affiliation: | 1. School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China;
2. Department of Oral and Maxillofacial Surgery, Tongji Hospital, Tongji University, Shanghai 200065, P. R. China |
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| Abstract: | β-Cyclodextrin(β-CD) can be used for drug loading and release in biomedical application. β-Cyclodextrinsalicylate(β-CD-S) was synthesized by transesterification and then was electrodeposited on the surface of stainless steel(SS) by the anodic electrooxidation polymerization of the salicylate. 1H NMR spectrometry was used to determine the structure of β-CD-S. FTIR spectroscopy and XPS were applied to verifying the synthesized β-CD-S and the existence of the electrodeposited layer on the SS surface, respectively. Tafel plots and electrochemical impedance spectroscopy(EIS) technologies were used to estimate the corrosion resistance of β-CD-covered stainless steel. Electrochemical quartz crystal microbalance was applied to determining the drug loading of the stainless steel before and after its modification. E. coli was selected as a harmful microbe to evaluate the antibacterial properties of the stainless steel with the comparison of optical density values. |
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| Keywords: | β-Cyclodextrin Surface modification Stainless steel Drug release Electrodeposition |
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