Syntheses and Fungicidal Activities of Thiazole-5-carboxanilides Bearing Thioether Group |
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Authors: | XUE Hansong LIU Aiping LIU Weidong LI Jianming REN Yeguo HUANG Lu HE Lian OU Xiaoming YE Jiao HUANG Mingzhi |
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Institution: | 1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China;
2. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, P. R. China;
3. Hunan Province Key Laboratory for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410014, P. R. China;
4. Hunan Haili Chemical Industry Co., Ltd., Changsha 410007, P. R. China |
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Abstract: | In an attempt to find leading thiazole carboxanilides exhibiting fungicidal activities, we designed and synthesized a new series of 2-sulfursubstituted thiazole carboxanilides via the reaction between 2-sulfur substituted thiazole carboxylic acid chlorides and substituted aniline. The fungicidal activities of the title compounds against Rhizoctonia solani were screened and the results were remarkable. The most potent compound 8i, N-2,6-dichloro-4-(trifluoromethyl)phenyl]-2-methylthio-4-(trifluoromethyl)thiazole-5-carboxamide, was identified. The fungicidal EC50 of compound 8i against Rhizoctonia solani was 1.28 mg/L, being comparable to that of Thifluzamide. The results indicate that compound 8i can be considered as a lead compound for further research. |
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Keywords: | Thiazole-5-carboxamide Fungicide Structure-activity relationship |
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