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Regioselective Synthesis of Functionalized Dihydroquinolines via Organocatalytic Allylic Alkylation |
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| Authors: | MA Xiaoyuan WU Yi ZHANG Yanjing TENG Lesheng XIE Jing LIAO Weiwei |
| Affiliation: | 1. Department of Pharmacology, School of Pharmaceutical Science, Jilin University, Changchun 130021, P. R. China; 2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China; 3. College of Life Sciences, Jilin University, Changchun 130012, P. R. China |
| Abstract: | The regioselective allylic alkylation of 1,2-dihydroquinolines and Morita-Baylis-Hillman(MBH) adducts has been developed. By surveying various reaction parameters, we summarized the effects of temperatures, relative reactant doses, catalysts, solvents and N-protected groups on the regioselectivity of this transformation. This method provides a facile protocol for the preparation of allylic α-substituted dihydroquinolines. |
| Keywords: | 1 2-Dihydroquinoline Regioselectivity Allylic alkylation |
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