Multicomponent reaction design in the quest for molecular complexity and diversity |
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| Authors: | Ruijter Eelco Scheffelaar Rachel Orru Romano V A |
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| Affiliation: | Department of Chemistry & Pharmaceutical Sciences and Amsterdam Institute for Molecules, Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands. |
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| Abstract: | Multicomponent reactions have become increasingly popular as tools for the rapid generation of small-molecule libraries. However, to ensure sufficient molecular diversity and complexity, there is a continuous need for novel reactions. Although serendipity has always played an important role in the discovery of novel (multicomponent) reactions, rational design strategies have become much more important over the past decade. In this Review, we present an overview of general strategies that allow the design of novel multicomponent reactions. The challenges and opportunities for the future will be discussed. |
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| Keywords: | chemoselectivity molecular complexity molecular diversity multicomponent reaction synthesis design |
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