Total synthesis of (+/-)-mycothiazole and formal enantioselective approach |
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Authors: | Le Flohic Alexandre Meyer Christophe Cossy Janine |
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Institution: | Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris 05, France. |
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Abstract: | Reaction: see text] A total synthesis of (+/-)-mycothiazole and a formal enantioselective approach have been achieved from 2,4-dibromothiazole. A chain extension of a homoallylic alcohol proceeding through an unsaturated sultone intermediate, generated by ring-closing metathesis, was used as a key step for the elaboration of the conjugated (Z)-dienol moiety. |
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