Amphidinolide B: asymmetric synthesis of a C7-C20 synthon |
| |
Authors: | Gopalarathnam Apsara Nelson Scott G |
| |
Affiliation: | Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA. |
| |
Abstract: | [reaction: see text] An asymmetric synthesis of a C(7)-C(20) synthon of amphidinolide B is described. The synthesis entails the construction of C(7)-C(13) and C(14)-C(20) fragments and makes extensive use of catalytic asymmetric bond constructions to establish the requisite stereochemical relationships. Fragment coupling proceeds by Suzuki cross-coupling and installs the trisubstituted diene unit that is among amphidinolide B's defining structural features. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|