| 姜黄素标准样品的研制 |
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| 引用本文： | 王岱杰,;周晓晶,;李强,;耿岩玲,;于金倩,;陈静娴,;王晓,;Dan Staerk.姜黄素标准样品的研制[J].化学分析计量,2014(4):1-5. |
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| 作者姓名： | 王岱杰 ;周晓晶 ;李强 ;耿岩玲 ;于金倩 ;陈静娴 ;王晓 ;Dan Staerk |
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| 作者单位： | [1]山东省分析测试中心,济南250014; [2]北京理化分析测试中心,北京100089 |
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| 基金项目： | 国家质检公益性行业科研专项（201310243）;山东省海外高层次人才资助专项资金项目;北京市科学技术研究院市级财政项目（PXM2013_178305_000009） |
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| 摘 要： | 采用硅胶柱色谱和重结晶的方法制备姜黄素标准样品,用UV,IR,MS和NMR等方法对姜黄素标准样品进行结构鉴定,并进行了均匀性、稳定性检验。采用国内8家具有分析资质的实验室进行协同定值,并对定值结果的不确定度进行了评定。姜黄素标准样品的定值结果为99.78%,置信度95%的扩展不确定度(k=2)为0.13%。该姜黄素标准样品可用于有关姜黄素检测方法的校正和相关产品的质量控制。
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| 关 键 词： | 姜黄素 标准样品 均匀性 稳定性 定值 不确定度 |
Preparation of Certiifed Referrence Materials of Curcumin |
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| Institution: | Wang Daijie, Zhou Xiaojing, Li Qiang, Geng Yanling, Yu Jinqian, Chen Jingxian, Wang Xiao, Dan Staerk (1. Shandong Academy of Sciences, Shandong Analysis and Test Center, Jinan 250014, China; 2. Beijing Center for Physical and Chemical Analysis, Beijing 100089, China) |
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| Abstract: | Curcumin certified reference material was separated by silica gel column chromatography and recrystallization method. Its chemical structure was identified by UV,IR,MS and NMR. The homogeneity and stability were systematic checked. A cooperative certification was conducted with 8 qualified laboratories. The results showed that the certified value of the reference material of curcumin was 99.78% with the expanded uncertainty of 0.13% （k=2） in confidence coefficient of 95%. The reference material of curcumin can conform to the technical requirement of the certified reference material. The materials can be used for method validation and quality control of regarding products. |
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| Keywords: | curcumin certified reference material homogeneity stability certification uncertainty |
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