Syntheses and characterisation of mercury complexes of sulfadiazine,sulfamerazine and sulfamethazine |
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Authors: | G.M. Golzar Hossain A.J. AmorosoA. Banu K.M.A. Malik |
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Affiliation: | School of Chemistry, Cardiff University, Main Building, Cardiff, Wales CF10 3AT, United Kingdom |
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Abstract: | The triple sulfa drugs, sulfadiazine, sulfamerazine and sulfamethazine, form a large number of metal complexes in different solvent media. The present studies show the synthesis and characterization of the Hg(II) complexes of sulfadiazine 1, sulfamerazine 2 and sulfamethazine 3 in dimethylformamide solution in presence of ammonia. The compounds were characterised by spectroscopic methods and crystal structures of the complexes were determined. All the compounds, 1, 2 and 3, crystallise in monoclinic crystal systems with the space groups of C2/c, C2/c and P21/c, respectively. Compounds 1 and 3 have eight coordinate ‘2+6’ geometries, with two tridentate sulfonamide ions and two DMF molecules in the coordination sphere. Complex 2 has a six co-ordinate, ‘2+4’ geometry which contains a short linear N–Hg–N moiety from co-ordinated sulfonamides. The IR spectral data suggest the binding of mercury atom to the sulfonamidic nitrogen atoms in agreement with the crystal structure determination. |
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Keywords: | Triple sulfa drug Mercury Sulfadiazine Sulfamerazine Sulfamethazine |
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