Synthesis,characterization, X-ray structure and preliminary in vitro antitumor activity of the nitrosyl complex fac-[RuCl3(NO)(dppf)], dppf = 1,1′-bis(diphenylphosphine)ferrocene |
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| Authors: | Gustavo Von Poelhsitz André Luiz Bogado Márcio Peres de Araujo Heloisa S Selistre-de-Araújo Javier Ellena Eduardo E Castellano Alzir Azevedo Batista |
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| Institution: | 1. Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905, São Carlos (SP), Brazil;2. Departamento de Química, Universidade Federal do Paraná, CP 19081, CEP 81531-990, Curitiba (PR), Brazil;3. Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, CP 676, CEP 13565-905, São Carlos (SP), Brazil;4. Instituto de Física de São Carlos, Universidade de São Paulo, CP 369, CEP 13560-970, São Carlos (SP), Brazil |
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| Abstract: | The reaction of RuCl3NO · 2H2O with stoichiometric amount of dppf, 1,1′-bis(diphenylphosphino)ferrocene, afforded the new neutral nitrosyl complex fac-RuCl3(NO)(dppf)] which was characterized by spectroscopical, electrochemical and X-ray crystallography techniques as well as elemental analysis. The νNO band in the IR spectrum is at 1860 cm−1 (CH2Cl2 solution) and in the cyclic voltammogram an irreversible wave was observed at −1.35 V, both are characteristics of a nitrosonium (NO+) character for the coordinated NO. Additionally, preliminary in vitro antitumor activity against the MDA-MB-231 breast tumor cell line was carried out for the new complex. The initial results indicated an important activity for fac-RuCl3(NO)(dppf)] (IC50 = 10 ± 3 μM ). The complex has a higher cytotoxicity than the precursor complex RuCl3NO · 2H2O, the free dppf ligand as well as the reference metallodrug cisplatin. |
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| Keywords: | Nitrosyl Ruthenium dppf Biological activity Antitumoral |
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