Synthesis,characterization and screening of biological activity of Zn(II), Fe(II) and Mn(II) complexes with trithiocyanuric acid |
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| Authors: | Pavel Kopel Karel Doležal Libor Machala Vratislav Langer |
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| Affiliation: | 1. Department of Inorganic Chemistry, Palacky University, K?í?kovského 10, CZ-771 47 Olomouc, Czech Republic;2. Laboratory of Growth Regulators, Institute of Experimental Botany ASCR and Palacky University, Šlechtitel? 11, CZ-783 71 Olomouc, Czech Republic;3. Department of Experimental Physics, Palacky University, Tr. Svobody 26, CZ-771 46 Olomouc, Czech Republic;4. Environmental Inorganic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden |
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| Abstract: | New Zn(II), Fe(II) and Mn(II) complexes with a combination of nitrogen-donor ligands and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis, IR and UV–Vis spectroscopies. The antitumor activity of the prepared complexes, together with already known Ni(II) species, were assayed in vitro against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukaemia) and MCF-7 (human breast adenocarcinoma) tumor cell lines. The IC50 values of the Fe(II) and Mn(II) compounds turned out to be lower than those of cisplatin and oxaliplatin. The antimicrobial activities were evaluated by MIC against bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis). The molecular structure of [Zn(taa)(ttcH)] · H2O (taa = tris(2-aminoethyl)amine) was determined by X-ray diffraction. The central atom is pentacoordinated by four N atoms of taa and one N atom of the ttcH dianion. |
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| Keywords: | Complexes Trithiocyanuric acid Cytotoxicity Crystal structure Mö ssbauer spectra |
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