Synthesis,characterization, DNA-binding and DNA-photocleavage studies of [Ru(bpy)2(BPIP)] and [Ru(phen)2(BPIP)] (BPIP = 2-(4′-biphenyl)imidazo[4,5-f][1,10]phenanthroline) |
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| Authors: | Li-Feng Tan Hui Chao Yang-Fan Zhou Liang-Nian Ji |
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| Institution: | 1. College of Chemistry, Xiangtan University, Xiangtan 411105, PR China;2. Department of Chemistry, Sun Yat-Sen University, Guangzhou 510275, PR China;3. Department of Chemistry, Tongji University, Shanghai 200092, PR China |
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| Abstract: | New ligand 2-(4′-biphenyl)imidazo4,5-f]1,10]phenanthroline (BPIP) and its complexes Ru(bpy)2(BPIP)]2+ (1) (bpy = 2,2′-bipyridine) and Ru(phen)2(BPIP)]2+ (2) (phen = 1,10-phenanthroline) have been synthesized and characterized by mass spectroscopy, 1H NMR and cyclic voltammetry. The interaction of two Ru(II) complexes with calf thymus DNA (CT-DNA) was investigated by spectroscopic and viscosity measurements. Results indicate that both complexes bind to DNA via an intercalative mode and the DNA-binding affinity of complex 2 is much greater than that of complex 1. Furthermore, when irradiated at 365 nm, both complexes have also been found to promote the photocleavage of plasmid pBR 322 DNA. |
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| Keywords: | Ruthenium(II) complex Polypyridyl ligand DNA-binding Photocleavage |
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