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Synthesis,characterization, crystal structure and antiproliferative in vitro activity of long-chain aliphatic thiosemicarbazones and their Ni(II) complexes
Authors:Marisa Belicchi-Ferrari  Franco Bisceglie  Giorgio Pelosi  Silvana Pinelli  Pieralberto Tarasconi
Institution:1. Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Viale G.P. Usberti 17A, Università degli Studi di Parma, 43100 Parma, Italy;2. Dipartimento di Clinica Medica, Nefrologia e Scienza della Prevenzione, via Gramsci 14, Università degli Studi di Parma, 43100 Parma, Italy
Abstract:In the course of a research on metal-based compounds active on white blood cell cancers (leukemia, lymphoma and myeloma) nine aliphatic thiosemicarbazones and their nickel complexes have been synthesized with the aim to test their effect on histiocytic lymphoma U937 cell proliferation. All compounds were characterized by elemental, IR and NMR spectra analyses and for five of the complexes also by X-ray crystallography diffraction analysis. Heptanal thiosemicarbazone and the corresponding nickel complex were chosen after a solubility/stability test to carry out preliminary experiments in vitro on human leukemia cell line U937. The complex possesses a remarkable biological activity in inhibiting cell growth and in inducing apoptosis.
Keywords:Nickel(II) complexes  Thiosemicarbazonato complexes  Crystal structure  Antineoplastic activity  Hydrogen bonding
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