具有图象处理功能的激光荧光内窥系统的研究

内窥镜荧光图象系统是体腔内早期肿瘤诊断和定位的有效手段.但是早期开发研究的LFE荧光成家系统由于存在假阳性和假阴性误诊而限制了它的广泛开展和应用.本文仔细探讨了该系统产生误诊的原因,并在此基础上提出了使用计算机图象处理技术的荧光图象系统,而且通过实验验证了这种新技术,它能有效地克服假阳性和假阴性误诊,为体腔内肿瘤的诊断提供可靠判据.

LASER FLUORESCENCE ENDOSCOPE WITH COMPUTER-ASSISTED IMAGE PROCESSING FOR DETECTION OF CANCER

The imaging system of LFE (Laser Fluorescence Endoscope) is a new useful tool for detection of early cancer, but a few false positive or negative results during human examination may appear in the current LFE system developed. The surrounding normal tissue near tumor emits auto fluorescence spectrum which peaks in blue when excited by violet laser. This emission greatly reduces or eliminates fluorescence intensity contrast between a tumor and its surrounding. In addition, the fluorescence intensity is also influenced by many other factors, such as non-uniform illumination,tissue size,target color and so on. All these may cause mistaken results of diagnosis. The purpose of this study is to improve diagnostic accuracy. We have developed a new technique based on computer assisted image processing. With the new imaging system it has been demonstrated employing an animal lung model. Our test results show that this new LFE system can significantly enhance the image contrast and reduce false positive and negative results for cancer diagnosis.